Manuscript accepted on : September 18, 2007
Published online on: 02-02-2016
Onyesom1*, C.C. Olise2, E.W. Edafiadhe3, C.O. Esume2 and E.B. Anyanwu4
1Department of Medical Biochemistry,Delta State University, Abraka, (Nigeria). 2Department of Pharmacology,Delta State University, Abraka, (Nigeria). 3Department of Psychiatry,Delta State University, Abraka, (Nigeria). 4Department of Family Medicine, Delta State University, Abraka, (Nigeria).
ABSTRACT: Heavy consumption of alcohol has been established to be the most common causative factor of liver disease, pancreatitis, upper gastrointestinal and neurological disorders. However, the influence of harmful duration of alcohol consumption on some “Syndrome X” risk factors and associated secondary cardiovascular dysfunction, is largely unknown. The study investigated the relationship of serum lipids in alcoholics and their duration of harmful alcohol consumption. One hundred and seven chronic alcoholics who were referred consecutively for detoxification were selected, and their drinking pattern was sufficient for them to be included in the study. History of alcohol abuse as well as drinking behaviour in the last 6 months were assessed by a semi-structured interview, and serum lipids were determined by standard procedures. Statistical analysis revealed that the duration of harmful alcohol consumption had the highest influence on the degree of brain injuries and withdrawal seizures. Serum cholesterol, triacylglycerol (TAG), HDL-,LDL- and VLDL-cholesterol, and blood pressure (BP) measures were elevated in alcoholics compared with control subjects. In recent times, increase in serum TAG and TAG/HDL-cholesterol ratio have been reported to be among the biochemical indicators of “Syndrome X”, an emerging disease. Thus, the prevalence of this emerging metabolic disorder among alcoholics deserve further investigation, because it might be yet another alcohol-related disorder study suggests.
KEYWORDS: Alcoholics; Pancreatitis;“Syndrome X”; Cholesterol; Triacylglycerol
Download this article as:
| Copy the following to cite this article: Onyesom I, Olise C. C, Edafiadhe E. W, Esume C. O, Anyanwu E. B. Relationship between duration of harmful alcohol consumption and serum lipids in some hospitalized Nigerian alcoholics undergoing detoxification treatment. Biosci Biotechnol Res Asia 2007;4(2) |
| Copy the following to cite this URL: Onyesom I, Olise C. C, Edafiadhe E. W, Esume C. O, Anyanwu E. B. Relationship between duration of harmful alcohol consumption and serum lipids in some hospitalized Nigerian alcoholics undergoing detoxification treatment. Biosci Biotechnol Res Asia 2007;4(2). Available from: https://www.biotech-asia.org/?p=5896 |
This work is licensed under a Creative Commons Attribution 4.0 International License.
