Introduction

Since ancient times Diabetes is an incurable chronic disease that affects almost every organ and system of the body. A number of plants have been beneficial in Diabetes Mellitus .A  Meta  analysis of selected clinical trials employing garlic preparation showed significant reduction of total serum cholesterol, in human subjects Garlic purportedly lowers circulating triglycerides. It is one of those herbs which have favorable effect as hypoglycemic and hypolipidemic agent. The main aim of this study was to see the effect of Garlic pods as hypoglycemic and hypolipidemic  in Diabetes Mellitus type 2. The jamun seeds possess many medicinal properties in Ayurveda system of medicine   The fresh seeds are most effective in diabetes as they quickly reduce sugar in urine   This study was designed to see the effect of jamaun seed powder and Garlic pods  on serum glucose and lipid profile in type 2 diabetic individuals.

Material and Method

A study was done to evaluate the hypoglycemic and hypolipoidemic effects of garlic pods and jamun seed powder. Among the 60 obese and diabetic subject of 35 years to 55 years. 10 were taken as healthy control and 25 diabetic and obese were treated with garlic pods and 25 were treated with jamun seed powder.  The criteria of inclusion of study group in subjects was FBS > 110 mg/dl of glucose, >290 mg/dl of cholesterol, > 210 mg/dl of triglyceride, <30 mg/dl of HDL, and > than 180 mg/dl of LDL.  All the subjects were examined for serum glucose and serum lipids. Garlic pods & jamun seed powder 100mgs/day was  given to the subjects of study group for 6 months and sample were collected  at the starting day of study after two  months , fourth and after six month of study  for estimation of all parameters.

Observation and Results

Table 1: Comparison of control group with the study group in initial phase i.e without oral administration of Herbs (WOAH)

Results of table reveal that Fasting blood glucose, post prandial blood glucose, HbA1c, Total cholesterol, Triglycerides &  LDL were highly significantly increased whereas HDL  level is significantly decreased and no change is observed in serum urea, creatinine and uric acid parameters when compared with control.

Observation

Table 3: Comparision Between Garlic And Jamun Supplement Groups After  A Period Of Four Months.

After four months

Fasting blood Glucose, Total Cholesterol, HDL Cholesterol, blood HbA_1c, Urea, Creatinine and Uric Acid  are non significant. There are no differences in these biochemical parameters. Post Prandial blood Glucose, Triglyceride, LDL and total Cholesterol are highly   significant  when compared after four months of supplementation.

Observation

Table 4  :Comparision Between Garlic And Jamun Supplement Groups After  A Period Of Six Month. 

After six months

Fasting blood Glucose, Post Prandial blood Glucose, HbA1c, urea, creatinine and uric acid  are also found to be non significant because the values of biochemical parameters are similar for both the herbs. Serum Total Cholesterol, Serum Triglycerides, Serum HDL Cholesterol, Serum LDL Cholesterol are  highly significant as there is much difference in the values of parameters of both the herbs after six months of supplementation

Discussion & conclusion

Results of the above study conclude that herbal treatment is effective and safe in initial stage of Diabetes mellitus type 2, and Eugenea jambolana (Jamun) is the best hypoglycemic agent in compared to Allium sativum (garlic) herbs.

Similarly Allium sativum (garlic) is  best for raising levels of the friendly lipid that is HDL. HDL in turn helps in lowering other harmful lipids due to which Diabetes patients have more chances of Obesity, Hypertension and cardiac disease. So use of Eugenea jambolana (Jamun),  and Allium sativum (garlic)   together will be beneficial for Diabetic patients.

References

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