Effect of Methanolic Extract of Saccharum Officinarum on the Biochemical Milieu and Histopathological Profile Of Female Albino Rats

K. Balamurugan et al.,

¹Annamalai University, Faculty of Engineering and Technology, Department of Pharmacy, Annamalai Nagar, Chidambaram, (India). ²Department of Pharmacology, Arupadaivedu Medical College and Hospital, Kirumambakkam, Puducherry (India).

ABSTRACT: The development of new fertility regulating drugs from medicinal plants is an attractive preposition. In the present study an attempt has been made to analyze the possible modulatory influence of methanolic extract of Saccharum officinarum on biochemical constituents (viz. glycogen, sialic acid, cholesterol, acid phosphatase and alkaline phosphatase profile which may play an important role in implantation and foetal development) and histopathology. Administration of methanolic extract of Saccharum officinarum(500mg/kg b.wt/p.o) from day 21st resulted in a statistically significant decline (p<0.01) in the acid phosphatase , alkaline phosphatase activity and glycogen content (p<0.001) when compared with control pregnant rats while the activity of cholesterol is increased as compared to the controls on day21st. Therefore, it can be suggested that the changes in the biochemical constituents of uterus may be responsible, for the anticontraceptive / anti-implantational effect of methanolic extract of Saccharum officinarum in the treated female rats.

KEYWORDS: Saccharum officinarum; fertility drugs; medicinal plants;

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